P-87: Nicotine and Caffeine Intake in Relation to Purported Decline of SemenQuality and Ovulatory Disorder Infertility

Background: Reproductive function and fertility are thought to be compromised by behaviors such as cigarette smoking, substance abuse, and caffeine consumption; however, the strength of these associations are uncertain. Many studies have examined whether caffeine and nicotine containing these affect fertility in men and women. Materials and Methods: In this study we evaluate the literature concerning the relationship between Nicotine and Caffeine intake and adverse effects on fertility as well as examining the evidence for a role of Nicotine and Caffeine in the purported decline of semen quality and the ovulatory disorder infertility, as well as analyzing the data Collected, with SPSS version 16. Results: Cigarette smoking (nicotine intake) among women and men was associated with decreased fecundability (95% confidence interval = CI). Caffeine consumption of 100 mg or less versus more than 100 mg in women and men was not associated with fecundability (95% CI). Decreases were observed among women who were coffee drinkers (95% CI) and men who were heavy tea drinkers (95% CI), regardless of caffeine content. There were 20% incident report of ovulatory disorder infertility during follow-up. Intakes of caffeine were unrelated to the risk of ovulatory disorder infertility. The multivariateadjusted relative risk, (95% CI), p for trend comparing the highest to the lowest categories of intake were 1.11 (0.76-1.64; 0.78) for Cigarette smoking and 0.86 (0.61-1.20; 0.44) for total caffeine. The multivariate-adjusted RR (95% CI), and p for trend comparing the highest to lowest categories of caffeinated soft drink consumption were 1.47 (1.09-1.98; 0.01). Conclusion: The association between nicotine and ovulatory disorder infertility appears to be attributable. Moderate and low caffeine intakes do not have effect on fecundability in men and women. Combined taking nicotine and caffeine are directly related to reduce fertility in both women and men.